Depressive conditions in their heterogeneous forms continue to grow and cause ongoing concerns in many life domains from physical health to mental health, to overall diminishment in quality of life. Despite efficacious, evidence-supported treatment for the more obvious and immediate depressive symptoms, relapse and treatment resistance remain a persistent concern. From the Millonian perspective, depressive and other mental health conditions are conceptualized for their context with an individual's personality style, type, or disorder. Enduring patterns of perceiving, feeling, thinking, and behaving are rooted in self-perpetuating, repetitive cycles that tend to develop into vulnerabilities contributing to the recurrence of common but pervasive depressive symptomology. This webinar will explore a personalized lens that targets depressive symptoms through a coordinated and integrated treatment structure based in understanding the personality structure and its effects on perpetuating symptomology.